ea0063p597 | Diabetes, Obesity and Metabolism 2 | ECE2019
Lorusso Riccardina
, Dassie Francesca
, Benavides-Varela Silvia
, Milan Gabriella
, Favaretto Francesca
, Vettor Roberto
, Semenza Carlo
, Maffei Pietro
Background: Alstrom syndrome (AS; OMIM#203800) is a rare (<1:100.000) autosomal recessive monogenic ciliopathy and it is caused by mutations in ALMS1 (chromosome 2p13), which function is still unknown. AS is characterized by multisystemic fibrosis, cone-rod retinal dystrophy leading to blindness, hearing loss, obesity, type 2 diabetes mellitus (T2DM), dilated cardiomyopathy, and progressive hepatic and renal failure. Most patients present neurological issue on developmenta...